From: https://healinggourmet.com/in-ketosis-not-losing-weight/

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Genetics and Weight Loss on Keto

Last but not least, your genetics can also play a role in weight.

Some people may have a genetic predisposition to weight gain or weight loss resistance, which can make it more challenging to lose weight. For example, some genetic variants have been shown to affect the way your body responds to a low-carb diet, making it more challenging to achieve and maintain ketosis.

If you are on keto and having trouble losing weight, check your 23andMe data (on 23andme.com. The single nucleotide polymorphism (SNP) rs9939609 in the FTO gene has been associated with a higher body mass index (BMI) and an increased risk of obesity. Similarly, variations in the LEP gene have been linked to a slower metabolism and increased fat storage.